Adjuvant epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for the treatment of people with resected stage I to III non-small-cell lung cancer and EGFR mutation This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness and safety of adjuvant EGFR tyrosine kinase inhibitors (TKIs) in patients with resected stage I to III non-small-cell lung cancer (NSCLC) harbouring an activating EGFR mutation. This is a protocol....

Clinical rating scales for assessing pain in newborn infants This is a protocol for a Cochrane Review (methodology). The objectives are as follows: To systematically review the current literature describing the development, content, and measurement properties of clinical rating scales for the assessment of pain in newborn infants. This is a protocol....

Non-pharmacological interventions for prophylaxis of vestibular migraine This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of non-pharmacological treatments used for prophylaxis of vestibular migraine. This is a protocol....

Non-pharmacological interventions for persistent postural-perceptual dizziness (PPPD) This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of non-pharmacological interventions for persistent postural-perceptual dizziness (PPPD). This is a protocol....

Pharmacological interventions for prophylaxis of vestibular migraine This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of pharmacological treatments used for prophylaxis of vestibular migraine. This is a protocol....

Thymosin-ɑ1 for people with chronic hepatitis B This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of thymosin-α1 in people with chronic hepatitis B, regardless of their age, sex, and ethnicity This is a protocol....

Pharmacological interventions for persistent postural-perceptual dizziness (PPPD) This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of pharmacological interventions for persistent postural-perceptual dizziness (PPPD). This is a protocol....

Pharmacological interventions for acute attacks of vestibular migraine This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of pharmacological interventions used to relieve acute attacks of vestibular migraine. This is a protocol....

Is attachment of the excretory duct of the pancreas to the second part of the small intestine better than other reconstruction methods to reduce leakage of juice from the pancreas to the abdominal tissues? Key messages - We do not know whether duct-to-mucosa pancreaticojejunostomy (attachment of the excretory duct of the pancreas to the second part of the small intestine) reduces postoperative pancreatic fistula (leakage of juice from the pancreas to the abdominal tissues) compared to invagination pancreaticojejunostomy (insertion of the pancreas within the second part of the small...

Doxapram for the prevention and treatment of apnea in preterm infants This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To determine the effects of doxapram administration on the incidence of apnea and longer-term clinical outcomes in preterm infants. This is a protocol....

Tranexamic acid for percutaneous nephrolithotomy This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of TXA in adults with kidney stones undergoing PCNL. This is a protocol....

What is the best way to use topical corticosteroids to treat people with eczema? Key messages - Generally, stronger topical corticosteroids (steroid cream applied to the skin) are probably more effective than weaker preparations. Strong steroid cream applied once daily is probably as good as twice daily, and using steroid cream for two consecutive days weekly probably prevents eczema flare-ups. - About a third of studies looked for skin thinning, but cases were very low. This made it difficult to judge differences between strategies, although there were more cases with stronger steroid...

Which treatments that affect the whole body work best to treat severe skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis)? Key messages Treating severe skin reactions with etanercept (a medicine that acts to reduce a specific part of the immune system), rather than steroids (which broadly reduces the immune system), may result in a lower number of deaths from Stevens-Johnson syndrome and toxic epidermal necrolysis. We are uncertain about the effectiveness of other treatments, such as steroids and cyclosporin (medicines that act on the immune system) or immunoglobulins...

Shunting for idiopathic normal pressure hydrocephalus This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To determine the effect of cerebrospinal fluid (CSF) shunting versus no CSF shunting in people with idiopathic normal pressure hydrocephalus (iNPH). To determine the frequency of adverse effects of CSF shunting in iNPH This is a protocol....

Point-of-care tests for detecting high viral load in people living with HIV attending healthcare facilities Why is improving the diagnosis of high HIV viral load infection important? It helps to monitor the HIV virus levels in people living with HIV (PLHIV) who are receiving antiretroviral therapy (ART). High virus levels indicate that the medications are failing to suppress the virus, a condition known as ART treatment failure, which has a risk of severe illness and death. Rapid diagnostic tests that detect high HIV virus levels quickly near the patient (point-of-care) can increase access...

Are inhaled corticosteroids an effective treatment for people with mild COVID-19? Key messages Inhaled corticosteroids (anti-inflammatory medicines) given via the oral inhaled route are evaluated for treatment of coronavirus disease 2019 (COVID-19). We identified three published studies for people with mild disease. Inhaled corticosteroids probably reduce the risk of people going to hospital or death (admission to hospital or death before hospital admission). Inhaled corticosteroids may lower the number of days people have symptoms of mild COVID-19 and probably increase resolution of...

Stakeholders’ perceptions and experiences of factors influencing the commissioning, delivery, and uptake of general health checks: a qualitative evidence synthesis This is a protocol for a Cochrane Review (qualitative). The objectives are as follows: To identify, appraise, and synthesise qualitative studies that explore the perceptions and experiences of healthcare managers or policy-makers, healthcare providers and clients with general health checks To identify how stakeholders understand, name, describe, and experience influencing factors relevant to the commissioning, delivery and uptake...

Associating liver partition and portal vein ligation for staged hepatectomy procedure versus conventional two-stage hepatectomy for colorectal liver metastasis This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure versus conventional two-stage hepatectomy in people with colorectal liver metastases This is a protocol....

Physical environmental designs in residential care to improve quality of life of older people What is the aim of the review? There is an increasing older population worldwide and an increase in the numbers of people living with dementia. It has been suggested that improving lived area designs may improve quality of life, mood, and ability to perform daily living activities of aged care residents. The aim of this Cochrane review was to examine the effects of different physical environmental design changes in residential aged care to determine the effect on quality of life for the residents....

Exercise for fatigue in people with cancer during and after active treatment This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Based on this single protocol, we will conduct five separate reviews, each on one of the following types of exercise. Aerobic exercise Anaerobic exercise Combined (aerobic and anaerobic) exercise Aerobic versus anaerobic exercise Yoga The primary aims of these reviews are to: evaluate the effects of aerobic exercise on CRF in people with cancer; evaluate the effects of anaerobic exercise on CRF in people with cancer; evaluate the...