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Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early-stage cervical cancer

Mon, 01/25/2021 - 08:01
The issue Radical hysterectomy with pelvic lymphadenectomy (removal of the uterus (womb) with its surrounding tissues and lymph glands in the pelvis) is the treatment for early-stage cervical cancer (when cancer is still within the cervix and upper vagina, without spread into nearby tissues).

What is the effect of atorvastatin on testosterone and other hormone levels in men and women?

Fri, 01/22/2021 - 21:01
Background Statins are one of the most prescribed classes of drugs, and atorvastatin is the most used drug in that class. People take statins to lower their blood cholesterol levels and reduce their risk of heart disease. However, statins may also lower levels of testosterone and other androgens.

Therapies for treating iron deficiency anaemia in Crohn's disease and ulcerative colitis

Wed, 01/20/2021 - 23:01
What is the aim of this review? The aim of this Cochrane Review was to find out whether treatments in people with Crohn's disease and ulcerative colitis can improve iron deficiency anaemia. We analysed data from 11 studies to answer this question. Key messages Iron in the form of ferric

Can hand hygiene prevent infection in newborn babies?

Wed, 01/20/2021 - 17:01
Review question Can hand hygiene prevent infection in newborn babies? Background Every year, about 500,000 newborn babies die as a result of infection caused by bacteria. Most of these deaths occur in poor countries. These infections can be prevented when caregivers of these babies practice good

Comparing standard and extended lymph node removal in people with cancer of the head of the pancreas and the periampullary region

Wed, 01/20/2021 - 15:01
Review question We attempted to find out whether more extensive surgical removal of lymph nodes had a positive effect on survival, recurrence, and eventual complications, and how their removal may affect the person’s quality of life. Background Pancreatic and periampullary adenocarcinomas reflect

Payment methods for healthcare providers in outpatient healthcare settings

Wed, 01/20/2021 - 11:01
What is the aim of this review? The aim of this Cochrane Review was to assess the effect of different payment methods for healthcare providers working in outpatient healthcare settings. The review authors collected and analysed all relevant studies to answer this question and found 27 studies. Key

IR methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults

Mon, 01/18/2021 - 17:01
What is the aim of this review? We reviewed the evidence about the effects of treating adults with ADHD with a stimulant drug called immediate-release (IR) methylphenidate. Key messages Compared with placebo (a dummy pill), IR methylphenidate may promote a small reduction in the symptoms of ADHD

Prophylactic antibiotics for people with COPD

Fri, 01/15/2021 - 14:01
Review question Which preventative antibiotic is effective and safe for reducing exacerbations, improving quality of life, and reducing serious side effects in people with COPD? What is COPD? COPD is a lung condition that can cause long-term breathing problems. Symptoms include shortness of breath,

Indomethacin for treatment of symptomatic patent ductus arteriosus (PDA) in preterm infants

Fri, 01/15/2021 - 05:01
Review question We wanted to see how safe and effective indomethacin is when compared with no treatment or placebo (a substance with no therapeutic effect) in treating symptomatic patent ductus arteriosus (PDA) in a preterm infant. Background PDA is a common complication among preterm and low birth

What are the best ways for recovering movement in the hand after surgery to repair flexor tendons (tendons in the hand that enable fingers to bend)?

Wed, 01/13/2021 - 01:01
Why is this question important? Flexor tendons are strong smooth cords that connect the muscles in the forearm (between the hand and elbow) to the bones in the fingers. These tendons allow us to bend our fingers. (Other tendons, known as extensor tendons, allow us to straighten them.) If flexor

Drugs and natural products for self-harm in adults

Sun, 01/10/2021 - 23:01
We have reviewed the international literature regarding pharmacological (drug) and natural product (dietary supplementation) treatment trials in the field. A total of seven trials meeting our inclusion criteria were identified. There is little evidence of beneficial effects of either

Treatment options for people with recurrent and progressive glioblastoma

Tue, 01/05/2021 - 17:01
Why this is important Glioblastoma multiforme (GBM) is a very aggressive type of brain tumour. Even after treatment involving surgery, radiotherapy and chemotherapy the tumour may continue growing (progress) and almost always comes back (recurs). In this review, we consider progression and

Remotely delivered information, training and support for informal caregivers of people with dementia

Mon, 01/04/2021 - 17:01
Review questions We were interested in remotely delivered interventions involving information, training and support for family caregivers of people with dementia. By remotely delivered, we meant that they were provided over the telephone or on a computer or mobile electronic device. We asked

Image-guided surgery for brain tumours

Mon, 01/04/2021 - 15:01
Background Surgery has a key role in the management of many types of brain tumour. Removing as much tumour as possible is very important, as in some types of brain tumour this can help people to live longer and to feel better. However, removing a brain tumour may be difficult because the tumour

Does behavioural support help people to stop smoking?

Mon, 01/04/2021 - 01:01
Key messages Behavioural support can help more people to stop smoking for six months or longer, without causing unwanted effects. Some types of support appear to work better than others. More studies are needed to identify the best ways to support people who are trying to stop smoking, and to

Does random drug and alcohol testing prevent injuries in workers?

Sun, 12/27/2020 - 14:01
Background Workplace accidents and injuries happen more often when people's physical abilities and judgement are impaired by drugs or alcohol. The workplace is not usually a place where research is conducted. There are many factors that make it difficult for an employer to measure the impact

Early full enteral feeds for preterm or low birth weight infants

Sun, 12/27/2020 - 13:01
Review question: do preterm or low birth weight infants (babies born early or small) grow faster and have fewer problems when they receive all their nutrients as milk feeds from shortly after birth (compared with gradually introducing milk feeds while giving fluid or nutrients via an intravenous

Prostatic arterial embolization for treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia

Wed, 12/23/2020 - 20:01
Review question What are the effects of a procedure that reduces blood flow to the prostate (called prostatic arterial embolization) in men with symptoms caused by an enlarged prostate? Background An enlarged prostate may cause difficulty with urination such as a weak stream or the need to urinate

What evidence is there that care bundles improve outcomes for patients with COVID-19 in the intensive care setting?

Tue, 12/22/2020 - 00:01
What are care bundles? Care bundles are a set of care practices that are carried out together (as a bundle) when delivering care to patients with the same condition or in the same healthcare setting. There are usually three to five practices in a bundle. Practices could include any aspect of

Non-pharmacological care for opioid withdrawal in newborns

Mon, 12/21/2020 - 23:01
Review question Do one or more specific non-pharmacological (treatments other than medicines) care practices benefit newborns with opioid withdrawal after birth? Background Newborns of mothers who take opioids during pregnancy often experience symptoms of withdrawal after delivery, such as high

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