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Treating long-term palmoplantar pustulosis (pustules on the hands and feet)

Mon, 01/20/2020 - 17:01
Review question We wanted to assess treatments for palmoplantar pustulosis (a persistent condition characterised by small, pus-filled blisters on the hands and feet), when compared to an inactive substance (placebo), no intervention, or each other. We included 37 studies. Background Palmoplantar

Motor neuroprosthesis for improving activities and participation of people in their natural environment after stroke

Tue, 01/14/2020 - 16:01
Review question Is motor neuroprosthesis (MN) effective for improving activities and participation of people in their natural environment after stroke? Background Stroke survivors usually face long-term impairment, activity limitation, and reduced participation. MN consists of electronic devices

Sclerotherapy versus beta-blockers for primary prophylaxis of oesophageal variceal bleeding in children

Fri, 01/10/2020 - 12:01
Background Portal hypertension is defined as an increase in the blood pressure within a system of veins (a type of blood vessel) called the portal venous system, which drains blood from the gastrointestinal tract (gut) and spleen into the liver. Portal hypertension commonly accompanies advanced

Cognitive behavioural therapy for adults with tinnitus

Wed, 01/08/2020 - 12:01
What is the aim of this review? The aim of this Cochrane Review was to find out if cognitive behavioural therapy (CBT) is effective for tinnitus. Cochrane researchers collected and analysed all relevant studies to answer this question. Key messages There is some low- to moderate-certainty evidence

Bacillus Calmette-Guérin or mitomycin C for treatment of non-muscle-invasive bladder cancer

Wed, 01/08/2020 - 11:01
Review question In people with cancer of the inner lining of the bladder, how do two different medicines, that are called Bacillus Calmette-Guérin (BCG) and mitomycin (MMC), that are put into the bladder, after the tumour is taken out, compare? Background Tumours of the superficial layers of the

Health-improving interventions helping unemployed job seekers to get a job

Wed, 01/08/2020 - 11:01
What is the aim of this review? The aim of this Cochrane review was to find out if it is possible to help unemployed people to get a job by improving their health. Decreased health and declined work ability may be reasons for becoming unemployed. Also, unemployment, and especially prolonged

Topical antiseptics for chronic suppurative otitis media

Sun, 01/05/2020 - 23:01
What is the aim of this review? The aim of this Cochrane Review is to find out whether topical antiseptics are effective compared to placebo or no treatment in treating chronic suppurative otitis media (CSOM). The review also looked to see whether one topical antiseptic was more effective than the

Topical antiseptics compared with antibiotics for people with chronic suppurative otitis media

Sun, 01/05/2020 - 23:01
What is the aim of this review? The aim of this Cochrane Review is to find out whether topical antiseptics are more effective than antibiotics in treating chronic suppurative otitis media. The review authors collected and analysed all relevant studies to answer this question. Key messages There is

Effects of involving parents and other adult caregivers in children's diet and physical activity interventions

Sun, 01/05/2020 - 19:01
Review question Does it make a difference if parents or other adult caregivers are involved in interventions to encourage children to eat healthier or be more physically active? Background Diet and physical activity behaviors are important determinants of health. Parents and other adult caregivers

Topical antibiotics for people with chronic suppurative otitis media

Fri, 01/03/2020 - 00:01
What is the aim of this review? The aim of this Cochrane Review was to find out if topical antibiotics are effective in treating chronic suppurative otitis media and whether one type of topical antibiotic treatment is more effective than any other. We collected and analysed all relevant studies to

Hypertonic saline versus other intracranial pressure-lowering agents for people with acute traumatic brain injury

Mon, 12/30/2019 - 15:01
Review question We reviewed the evidence for the effectiveness and safety of infusions of hypertonic saline (concentrated salt (sodium chloride) solution) compared with other types of infusion for lowering intracranial pressure (ICP) (pressure in and around the brain) in the management of acute

Brain scans for people with cerebral gliomas

Tue, 12/24/2019 - 16:01
Background Gliomas are brain tumours arising from the supporting brain tissues. They are termed low grade (WHO 1 and 2) or high grade (WHO 3 and 4), depending on their cell activity and how aggressive the tumour is. Gliomas are diagnosed in 4 to 11 people for every 100,000 each year, more commonly

Pharmacies might be able to support people with their depression medicines

Mon, 12/23/2019 - 13:01
Background Some people with depression find it difficult to take their depression medicines (often called 'antidepressants') as prescribed by their doctor. This can mean that the medicines do not work properly and people might not get better or might even get worse. It could be that

Intravenous iron for the treatment of non-anaemic iron deficiency in adults

Fri, 12/20/2019 - 21:01
Background Iron deficiency, when the body does not have enough of the mineral iron, is a common, nutritional deficiency. Iron is used by the body to make haemoglobin, a protein in red blood cells that enables them to carry oxygen around the body. Whilst iron deficiency is most commonly associated

Transcatheter aortic valve implantation versus surgical aortic valve replacement in people with severe aortic stenosis and low surgical risk

Fri, 12/20/2019 - 17:01
Review question Does transcatheter approach, compared to open-heart surgery, for aortic valve replacement improve outcomes in people with severe aortic stenosis and low surgical risk? Background Aortic stenosis (AS) is the narrowing of the exit of the left ventricle of the heart (where the aorta

Racecadotril to treat children under five years of age with acute diarrhoea

Fri, 12/20/2019 - 06:01
What was the aim of this review? The aim of this Cochrane Review was to find out whether racecadotril works for children under five years of age with diarrhoea. Cochrane Review authors collected and analysed all relevant trials to answer this question and included seven trials in this review. Key

Effectiveness of equivalent schedules of full-dose inactivated poliovirus vaccine injected into muscle compared to a smaller dose injected into skin

Fri, 12/20/2019 - 06:01
Background Polio is a disabling disease that is only preventable via vaccination. There are two types of polio vaccines: live poliovirus vaccine delivered orally (by mouth – so-called OPV) and inactivated (killed) poliovirus vaccine (IPV). OPV is the mainstay of polio eradication but carries a risk

Non-vitamin K antagonist oral anticoagulants (NOACs) after a heart vessel stent placement

Fri, 12/20/2019 - 06:01
Background Choosing the optimal treatment for people on long term blood thinners (due to atrial fibrillation), who require a heart vessel stent placement (after a heart attack or angina) remains a challenge in clinical practice. They need to take blood thinners to prevent a stroke, and antiplatelet

The effect of manually-generated reminders delivered to providers on paper on professional practice and patient outcomes

Fri, 12/20/2019 - 05:01
What is the aim of this review? In this Cochrane Review we aimed to find out if health workers who are given reminders on paper give better health care. The reminders contained information about the patients, for instance recommendation to measure blood pressure. We collected and analysed all

Title: Impact of food fortification with multiple micronutrients on health

Wed, 12/18/2019 - 04:01
Review question Does multiple micronutrient fortification improve health? Background Vitamins and minerals are important for growth and body functioning. Micronutrient deficiencies are common in many populations, and food fortification is one of the interventions to reduce the burden of

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