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Why this review is important Medical abortion is offered routinely in clinics and hospitals, but could be offered in other settings such as pharmacies. In many countries, pharmacies are a first and common point of access for women seeking reproductive health information and services, including
What is the aim of this Cochrane Review? To find out if any lifestyle modifications decrease the effect of nonalcohol-related fatty liver disease on lifespan, health-related quality of life, chronic liver disease and its complications, and whether they cause any harms. Nonalcoholic fatty liver
Treating long-lasting blepharitis (swollen and itchy eyelids): how well do antibiotics (medicines that kill bacteria) work when taken by mouth (orally)?
Key messages · We did not find enough evidence to show how well antibiotics taken by mouth can treat long-lasting blepharitis. · One antibiotic tested may improve some clinical aspects (symptoms and course of the disease), but we are uncertain about its benefit in this respect, and it may also
Can tests to identify the main draining lymph nodes in women with endometrial cancer accurately diagnose if the cancer has spread to the lymph nodes?
The issue Women who have endometrial cancer (cancer arising from the lining of the womb) may have cancer cells spread to lymph nodes in the pelvis and/or the para-aortic area (main blood vessel in the upper abdominal cavity) and need additional radiotherapy treatment, with or without chemotherapy,
Background An aortic aneurysm is an abnormal bulge or swelling that occurs in the wall of the aorta. An aneurysm can be classified by its shape, location (sometimes reported as zone) and size. A thoracic aortic arch aneurysm (TAA) is a swelling in the upper portion of the thoracic aorta. The
What is the issue? Miscarriage is the most common cause of pregnancy loss and one of the most common complications in early pregnancy. An estimated 15% of pregnancies will end in miscarriage, with 25% of women experiencing a miscarriage in their lifetime. Miscarriage can lead to serious
Review question Does intimate partner violence (IPV) training for healthcare providers (HCPs) improve their: · attitudes or beliefs, or both, towards IPV, · readiness to respond to those affected by IPV, · knowledge of IPV, · referral of women being subjected to IPV to specialist services, · actual
Key messages Programmes on social media (such as Facebook or Twitter) that aim to increase physical activity may help people to become more physically active and may improve people's well-being. Future studies are needed to find out if there are any unwanted effects associated with taking part
Does placing a tiny tube (microstent) under the surface of the eye relieve long-lasting high pressure inside the eye (glaucoma)?
What is open-angle glaucoma? Glaucoma is a common eye condition caused by fluid building up in the front part of the eye, which increases pressure inside the eye. The increased pressure damages the nerve that connects the eye to the brain (optic nerve), causing loss of sight. Glaucoma can lead to
Review question What are the benefits and harms of different techniques for fixing meshes (patches) in the belly wall in the course of ventral hernia repair. Background A hernia is a bulge or weakness, in which tissues or organs from inside the abdomen (the belly) can get trapped, and can cause
What is the best way to place medicines directly into the eye to widen the pupil during cataract surgery?
Key messages We did not find enough good-quality evidence about the best way to deliver medicines directly to the eye during cataract surgery. We found only one study that had enrolled a large enough number of people to give reliable results. Larger, well-designed studies are needed to give better
Benefits of capecitabine in hormone receptor-positive compared to hormone receptor-negative breast cancer
What is the aim of this review? The aims of this Cochrane Review were to find out whether capecitabine is more useful in hormone receptor-positive or-negative breast cancers, and to see whether this differs depending on how advanced the cancer is. We collected and analysed all relevant studies to
Key messages Due to weak evidence, we do not know if:- azoles taken as a cream or drops are better than no treatment or a placebo (dummy) treatment;- some azoles are better at ending infections than others. There is a need for well-conducted studies that investigate the risks and benefits of these
Review question We reviewed the evidence for the effects of different medications on daytime sleepiness in people with idiopathic hypersomnia. Background We wanted to know which medications are helpful for treating people with idiopathic hypersomnia, a disease that causes severe daytime sleepiness,
Newer generation antidepressants for depression in children and adolescents: a network meta-analysis
How well do newer formulations of antidepressants work for children and adolescents with clinical depression? Children and adolescents (6 to 18 years) with depression (also called ‘major depressive disorder’) experience a range of negative impacts in all areas of their lives and have an increased
Key messages- We did not find enough, good-quality evidence to judge whether vitamin D is an effective or safe treatment for adults with COVID-19.- We need more research on this topic. Future research should focus on well-designed studies with robust methods.- We identified 21 studies on this topic
How accurate are tests to measure the level of ferritin (a protein that stores iron) in the blood at diagnosing iron deficiency and overload?
Key messages- Tests that measure the level of ferritin in the blood may be reasonably accurate for diagnosing iron deficiency (low iron levels) in people:- seeking medical care; and- whose doctors suspect iron deficiency.- The accuracy of ferritin blood tests for diagnosing iron overload (high iron
Review question We looked at the evidence on ways to increase physical activity in people with neuromuscular disease. We only included studies that measured physical activity as an outcome. We collected and analysed all relevant studies to answer this question. Background Physical activity includes
Review question In people with orthostatic hypotension, does fludrocortisone prevent or reduce a symptomatic drop in blood pressure that occurs with changes in position (for example, from sitting to standing) and does it have unwanted effects? Background Orthostatic, or postural, hypotension is a
What are the benefits and risks of a single injection of ketorolac (an anti-inflammation medicine) for relieving short-term pain after surgery in adults?
Key messages · Ketorolac may reduce short-term pain after surgery by 50% (half) or more in more people than a placebo (dummy treatment). · There may be little to no difference between ketorolac and other anti-inflammation medicines in the number of people whose pain is reduced by half or more. ·