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Treatment for bleeding from enlarged veins in the oesophagus (food pipe) in people with advanced scarring of the liver

Sat, 04/10/2021 - 06:01
What is the aim of this Cochrane Review? To find out the best available treatment for bleeding from oesophageal varices (enlarged veins in the oesophagus) in people with advanced scarring of the liver (liver cirrhosis, or late-stage scarring of the liver with complications). Bleeding from

Is bed sharing an effective and safe method in the care of healthy term neonates?

Thu, 04/08/2021 - 17:01
Review question: we wanted to find out if bed sharing is associated with an increase in the duration and frequency of breastfeeding in babies who are born after 37 weeks of pregnancy (also known as term neonates) and are healthy at birth. Background: 'bed sharing' is a type of sleeping

Treatment to prevent first bleeding from dilated veins in the oesophagus resulting from advanced scarring of the liver

Tue, 04/06/2021 - 12:01
What was the aim of this Cochrane Review? We aimed to find the best available treatment for prevention of first bleeding from oesophageal varices (enlarged veins in the food pipe (oesophagus)) in people with advanced liver scarring (liver cirrhosis, or late stage scarring of the liver with

Interventions for increasing solid organ donor registration

Sun, 04/04/2021 - 15:01
What is the issue? There is a global need to increase the number of available organs for transplantation. One possible strategy is to encourage more individuals to register as organ donors. What did we do? To address this, we identified 46 studies that tested various strategies to encourage people

Exercise training for bronchiectasis

Fri, 04/02/2021 - 12:01
Review question We wanted to know if exercise training improves exercise tolerance, quality of life, or symptoms, and if it reduces the number of future flare-ups ('exacerbations'), for people with bronchiectasis compared to people who did not do exercise training. We looked at studies

Treatment for primary autoimmune haemolytic anaemia

Wed, 03/31/2021 - 09:01
What is primary autoimmune haemolytic anaemia (AIHA)? Red blood cells carry oxygen to all parts of the body. In healthy people, red blood cells live about 120 days. In AIHA the immune system does not work properly and destroys red blood cells faster than rhe body can make them. Primary AIHA is when

Are circumcision devices safer or faster when compared to standard surgical circumcisions for males older than 10 years?

Wed, 03/31/2021 - 05:01
Background Male circumcisions have been performed for many centuries and are one of the most common surgical procedures in males. Medical doctors usually perform circumcisions by removing the foreskin found on the penis in a surgical procedure. Some doctors use circumcision devices specifically

Prevention of rebleeding from enlarged veins in the food pipe (oesophagus) resulting from advanced liver disease

Tue, 03/30/2021 - 22:01
What is the aim of this Cochrane Review? To find out the best available preventive treatment for repeated bleeding from oesophageal varices (enlarged veins in the food pipe) in people with advanced liver disease (liver cirrhosis, or late-stage scarring of the liver with complications). People with

What is the most effective treatment for atypical haemolytic uraemic syndrome?

Tue, 03/30/2021 - 15:01
What is the issue? Haemolytic uraemic syndrome (HUS) is a condition involving blockages in small blood vessels leading to destruction of blood cells and dysfunction of several organs, most notably the kidneys. It is commonly caused by infections, often E.Coli, and can be associated with diarrhoea.

Weight loss interventions for people with chronic kidney disease who are overweight or obese

Tue, 03/30/2021 - 01:01
What is the issue? People who are overweight or obese with chronic kidney disease (CKD) may experience a faster progression to kidney failure than those who are a healthy weight. Some people with more advanced kidney disease may require treatment such as dialysis or a kidney transplant. Being obese

Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated neonates

Mon, 03/29/2021 - 23:01
Review question In mechanically ventilated neonates, do lung recruitment manoeuvres (LRMs) help to reduce mortality and respiratory morbidity, compared to no recruitment?  Background Critically ill neonates (infants from birth up to four weeks of age) commonly require intubation (placement of a

Review question

Thu, 03/25/2021 - 22:01
To assess the effectiveness and safety of pharmacological and non-pharmacological strategies compared with each other, placebo, or no treatment for weight reduction in obese women with subfertility. Background To prevent the adverse effects of obesity, weight loss is recommended as the first line

What surgical procedure works best to slow the progression of keratoconus (an eye disease)?

Thu, 03/25/2021 - 17:01
Why is this question important? Keratoconus is a disease that affects the thin, clear outer layer of the eye, known as the cornea. Normally, the cornea is dome-shaped. In people with keratoconus, the cornea slowly thins, and a cone-shaped bulge develops in the center of the cornea. The disease

What are the benefits and risks of surgery for epiretinal membrane (a disease of the eye)?

Wed, 03/24/2021 - 12:01
Why is this question important? An epiretinal membrane is an abnormal layer of tissue that develops at the back of the eye. It affects around one in five people aged 75 years and older. In most people, the development of an epiretinal membrane is linked to the normal ageing processes in the eye and

How accurate are sputum Xpert tests for screening for active pulmonary tuberculosis and rifampicin resistance in adults whether or not they have tuberculosis symptoms?

Tue, 03/23/2021 - 15:01
Why is using Xpert tests to screen for pulmonary tuberculosis important? Tuberculosis is the leading cause of infectious disease-related death and one of the top 10 causes of death worldwide. The World Health Organization (WHO) recommends using specific rapid tests as initial tests for diagnosing

Selective serotonin re-uptake inhibitors for premature ejaculation

Sun, 03/21/2021 - 20:01
Review question We wanted to find out if medicines called selective serotonin re-uptake inhibitors (SSRIs), which are used mostly to treat depression, can help men that ejaculate faster than they want, to slow down. Background Premature ejaculation is a common problem among men, that occurs when

Opioids for newborns receiving mechanical ventilation

Wed, 03/17/2021 - 12:01
Review question Do drugs such as morphine and fentanyl (opioids) save lives, reduce pain, or improve the long-term development of newborns needing breathing machines (mechanical ventilators)? Background Breathing machines are widely used for newborn full-term (≥ 37 weeks' gestational age) and

Electrical conductance for the detection of early tooth decay

Tue, 03/16/2021 - 12:01
Why is it important to improve dental caries (tooth decay) detection? Dentists often aim to identify tooth decay that has already advanced to a level which needs a filling. If dentists were able to find tooth decay when it has only affected the outer layer of the tooth (enamel) then it is possible

Do psychosocial interventions help parents reduce how often they drink heavily or use drugs?

Tue, 03/16/2021 - 09:01
Aim of the review Psychosocial interventions are talking or practical interventions, or both, delivered to individuals or groups. The interventions examined in this review seek to help parents to change their drinking or drug use and address any related problems they are having regarding the care

Dental imaging methods for the detection of early tooth decay

Mon, 03/15/2021 - 13:31
Why is it important to improve the detection of dental caries (tooth decay)? Dentists often aim to identify tooth decay that has already advanced to a level which needs a filling. If dentists were able to find tooth decay when it has only affected the outer layer of the tooth (enamel) then it is

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