Interventions for treatment of herpes labialis (cold sores on the lips) This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of interventions for treating herpes labialis among immunocompetent people. This is a protocol....

Face-down positioning or posturing after vitrectomy for macula-involving rhegmatogenous retinal detachments This is a protocol for a Cochrane Review (intervention). The objectives are as follows: The primary objective of this review is to determine whether face-down positioning reduces the risk of retinal displacement following pars plana vitrectomy (PPV) and gas tamponade for macula-involving rhegmatogenous retinal detachment (RRD). This is a protocol....

Physical activity for the management of cancer-related fatigue in adults This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To assess the effects of physical activity interventions for cancer-related fatigue (CRF) in adults. Secondary objective To assess whether the effects of CRF interventions differ according to: type of comparator: no intervention, usual care, or another CRF intervention: phase or type of cancer treatments: when receiving disease-modifying oncological treatment with curative intent; after receiving disease-modifying...

Vaginal cervical support device to prevent delivery of a single baby before 37 weeks What is preterm birth? Preterm birth means birth before 37 weeks of pregnancy. It is the leading cause of death in newborn babies. Often, preterm birth is caused by weakness of the cervix (the lower, narrow end of the womb). How can cervical weakness be treated to prevent preterm birth? Methods used to treat cervical weakness include cervical cerclage (tightening the cervix with a stitch to prevent its premature opening), expectant management (monitoring without intervention until problems arise), medical...

Surgery for long-term joint disease in people with haemophilia How does surgery compare to non-surgical treatment in terms of safety and efficacy for people with chronic (long-term) joint disease from a rare condition that affects the ability of the blood to form clots (haemophilia)? Key messages We did not find any relevant studies. More research is needed in this field. Future studies should compare surgical and non-surgical treatments for chronic arthropathy in people with haemophilia. Background Haemophilia is a disease that affects the ability of blood to clot. People with severe...

Blood pressure targets for people undergoing heart surgery Review question What effect does a high blood pressure target compared with a low blood pressure target have in people undergoing heart surgery while on cardiopulmonary bypass (CPB). Key messages A high blood pressure target compared with a lower target may result in little to no difference in kidney injury, cognition (ability to learn and understand) damage, or survival. A high blood pressure target may increase the length of hospital stay slightly. What is heart surgery? Heart surgery is a common type of surgery throughout the...

Coriolus versicolor mushroom in colorectal cancer Review question Does adding Coriolus to colorectal (bowel) cancer treatment reduce side effects and improve survival? Background Radiotherapy and chemotherapy are used to treat colorectal cancer but side effects can be a problem. Coriolus versicolor mushroom (also known as Trametes versicolor or 'Turkey Tail') and its extracts have been used by cancer patients to help with side effects. Search date We searched medical databases for trials comparing Coriolus plus chemotherapy or radiotherapy to chemotherapy or radiotherapy alone in adults...

Food-based calcium or vitamin D or both for osteoporosis in postmenopausal women This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of calcium- or vitamin D-rich foods, or both, for preventing osteoporosis in postmenopausal women. This is a protocol....

Interventions to prevent or cease electronic cigarette use in children and adolescents This is a protocol for a Cochrane Review (intervention). The objectives are as follows: The co-primary objectives of the review are to: 1. Evaluate the effectiveness of interventions to prevent e-cigarette use in children and adolescents (aged 19 years and younger), relative to usual practice or no intervention. 2. Evaluate the effectiveness of interventions to cease e-cigarette use in children and adolescents (aged 19 years and younger), relative to usual practice or no intervention. Secondary objectives...

Exercise training for adult kidney transplant recipients This is a protocol for a Cochrane Review (intervention). The objectives are as follows: This review aims: To assess the benefits and harms of regular physical activity interventions in adult kidney transplant recipients when compared with any other or no intervention. To determine whether benefits and harms vary in absolute or relative terms dependent on specific characteristics of the physical activity intervention (i.e. frequency, intensity, type, time, volume, progression and pattern of the intervention). To determine whether...

Pre-emptive versus empirical antifungal therapy in people with cancer who have febrile neutropenia Intensive chemotherapy for people with cancer can cause severe and prolonged cytopenia (lower-than-normal number of blood cells), especially neutropenia (lower-than-normal white blood cells, which help to fight infection), a critical condition that is potentially life-threatening. When a person has both fever and neutropenia, it is called febrile neutropenia (FN). Invasive fungal disease (IFD; an infection caused by a fungus) is one of the serious causes of chemotherapy-induced FN. There are...

Day 5 versus day 3 embryo biopsy for genetic testing for single gene disorders before embryo implantation Background Couples who have a personal or family history of a single-gene genetic disease, such as cystic fibrosis, can now undergo assisted reproductive technology (ART) to reduce the chance of them having a child with that same genetic disorder. This is known as preimplantation genetic testing for single gene disorders (PGT-M). During PGT-M, cells from a fertilised embryo are removed (biopsied) and analysed for the genetic disorder before those embryos that do not have the disorder are...

Reduction in the dose of antipsychotics for people with schizophrenia Key messages Reducing the dose of antipsychotics may be associated with a higher number of study participants relapsing and leaving the study early. Very little information was available on quality of life, functioning, and side effects. Introduction to the review topic Schizophrenia is a severe disease that needs treatment with medication (antipsychotics). Use of antipsychotics is connected with side effects, and it appears that these side effects may be worse with higher doses. On the other hand, the dose needs to be...

Cephalosporin antibiotics for the treatment of enteric fever (typhoid fever) Key messages • There may be no difference in the performance of ceftriaxone (a type of cephalosporin) compared with azithromycin, fluoroquinolones, or chloramphenicol (other antimicrobial medicines) for adults and children with enteric fever (typhoid fever). • Cefixime (another type of cephalosporin) can also be used for treatment of enteric fever in adults and children but may not be as effective as fluoroquinolones. • Policymakers and clinicians need to consider local antibiotic resistance patterns when...

Interventions for preventing and treating acute kidney injury in children This is a protocol for a Cochrane Review (intervention). The objectives are as follows: This review aims to look at the benefits and harms of all pharmacological interventions except dialysis for the prevention and treatment of AKI. This is a protocol....

Liver support systems for adults with acute-on-chronic liver failure This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of liver support systems for adults with acute-on-chronic liver failure. This is a protocol....

Can medicines prevent venous thromboembolism after weight-loss surgery? What is venous thromboembolism? Venous thromboembolism (VTE) is a clinical condition that usually starts when a blood clot forms inside a vein. The condition includes both deep vein thrombosis (when the clot forms in a deep vein, usually in the legs) and pulmonary embolism (when the clot forms in or reaches a blood vessel in the lungs). Both situations can substantially reduce quality of life and can be life-threatening. People with obesity or who undergo surgery are more likely to experience VTE. Therefore, people...

Psychedelic/entactogen-assisted therapy for treatment of anxiety, depression and existential distress in adult palliative care This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of psychedelic/entactogen-assisted therapy compared to placebo or active comparators (e.g. antidepressants) for treatment of anxiety, depression, and existential distress in adult palliative care. This is a protocol....

Transversus abdominis plane (TAP) blocks for prevention of postoperative pain in women undergoing laparoscopic and robotic gynaecological surgery This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of TAP blocks for the prevention of postoperative pain in women undergoing laparoscopic and robotic gynaecological surgery compared to no block, sham block, or injection of local anaesthetic. This is a protocol....

Blood pressure lowering effect of hydrochlorothiazide compared to other diuretics for hypertension This is a protocol for a Cochrane Review (intervention). The objectives are as follows: This review aims to assess the short-term (3 to 12 weeks) blood pressure lowering efficacy of hydrochlorothiazide in comparison with other diuretics for primary hypertension in adults, and will build upon the other Cochrane Reviews studying the blood pressure lowering effect of diuretics (Chen 2009; Musini 2009; Musini 2014). The main outcomes of this review will be change in blood pressure, heart rate, and...