Lovastatin for lowering lipids This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To evaluate the benefits and harms of different doses of lovastatin on lipid parameters and withdrawals due to adverse effects (WDAEs) in people of any age compared to placebo. This is a protocol....

Interventions for improving walking after stroke: an overview of Cochrane Reviews This is a protocol for a Cochrane Review (overview). The objectives are as follows: To summarise and appraise the evidence from Cochrane Reviews assessing the effects of interventions for the recovery and/or the improvement of walking in people after stroke. We will conduct an overview of Cochrane Reviews involving stakeholders to: provide accessible high-quality evidence on the effects of interventions aiming to recover and/or improve walking in people after stroke; summarise the evidence of the effects of...

Is skin-sparing mastectomy an effective and safe surgical procedure for the treatment of breast cancer? What is the aim of this review? We reviewed the evidence about the surgery technique called skin-sparing mastectomy (SSM) (that is, removing the breast tissue including the breast and areola (skin surrounding the nipple) but preserving all the skin that overlies the breast) compared to conventional mastectomy (that is, removing the skin that overlies the breast including nipple and areola). Key messages We found that SSM may not be different from conventional mastectomy for the risk of...

Surgical interventions for presbyopia This is a protocol for a Cochrane Review (intervention). The objectives are as follows: The primary objective is to evaluate the effectiveness and safety of surgical interventions for people with presbyopia. The secondary objective is to produce a brief economic commentary, summarizing relevant economic evaluations that compare different surgical interventions. This is a protocol....

Caffeine versus other methylxanthines for the prevention and treatment of apnea in preterm infants This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of caffeine compared to aminophylline or theophylline in preterm infants at risk of apnea, with apnea, or in the peri-extubation phase. This is a protocol....

Meta-cognitive training for schizophrenia This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of MCT and MCT+ for people with schizophrenia or related disorders compared to standard care or other psychosocial interventions. This is a protocol....

Service delivery, behavioural, and self-management interventions for children with epilepsy This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of different behavioural interventions, self-management education and models of service delivery in promoting seizure control and improving quality of life-related outcomes for children with epilepsy compared to usual care or another behavioural intervention. This is a protocol....

Service delivery, behavioural, and self-management interventions for adults with epilepsy This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of different behavioural interventions, self-management education and models of service delivery in promoting seizure control and improving quality of life-related outcomes for adults with epilepsy compared to usual care or another behavioural intervention. This is a protocol....

What are consumers and health providers' views and experiences of working in formal partnerships to plan, deliver and evaluate health services? Key messages -Power imbalances between health providers and consumers can limit consumer participation in health service planning, delivery and evaluation. -Power imbalances in the partnership may happen because of the ways consumers are recruited, how meetings are run, and how decisions are made. -To have successful partnerships with consumers, health providers need to address these power imbalances. -Some consumers and health providers...

Therapeutics for treating mpox What is the aim of this review? There are no drugs licenced specifically for treating mpox, but some drugs that are licenced for treating similar viral infections, such as smallpox, are authorized for treating mpox during an outbreak. The effects of these drugs have not yet been studied in randomized trials in people with mpox. Randomized trials include at least two treatment groups, such as one receiving the drug and one receiving a placebo, where the people recruited for the trial are randomly allocated to either group. This review summarizes evidence on the...

Oral Class I and III antiarrhythmic drugs for maintaining sinus rhythm after catheter ablation of atrial fibrillation Review question We wanted to find out how effective certain classes of antiarrhythmic drugs (medications used to prevent or treat an irregular heart rhythm) are for maintaining sinus rhythm (normal heart rhythm) in people after catheter ablation (a technique using catheters to create controlled burns in the heart to prevent and treat arrhythmia occurrence) for atrial fibrillation (a common type of irregular heart rhythm), compared to catheter ablation alone. Background The...

Exercise interventions for adults with cancer who are receiving radiation therapy without additional cancer therapy What is radiation therapy? Radiation therapy (also called radiotherapy) is a treatment that delivers high doses of radiation to a specific part of the body to kill cancer cells. One in two people with cancer will undergo radiation therapy. Some people receive radiation therapy alone, while others receive radiation therapy combined with other cancer treatments that affect the whole body (chemotherapy, immunotherapy, or hormone therapy). The unwanted effects of radiation therapy...

Remote digital monitoring for selected chronic diseases in primary health care This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of remote digital monitoring for adults with selected chronic diseases (hypertension, type 2 diabetes, chronic obstructive pulmonary disease, congestive heart failure, and asthma) in primary healthcare settings. This is a protocol....

What are the benefits and risks of treatments other than medication for persistent postural-perceptual dizziness (PPPD)? Key messages There are very few studies that look at treatments for persistent postural-perceptual dizziness (PPPD). We only found one very small study, which looked at the use of electrical stimulation of the brain (called transcranial direct current stimulation). Further work is needed in this area to help establish whether there are any treatments that may be effective at treating this condition, and to check if they cause any unwanted or harmful effects. What is PPPD?...

Prediction of disease specific and overall survival in men with prostate cancer using the Decipher assay This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: To determine the prognostic value of the Decipher gene assay in men with biopsy-confirmed clinically localized prostate cancer before and after receiving treatment. This objective can be framed in two questions following the population, index prognostic factor, comparator prognostic factor(s), outcome, timing, and setting (PICOTS) format as illustrated in Table 1. Table 1. Review question in PICOTS format...

Reducing fall hazards within the environment Key messages For older adults at a higher risk of having a fall, such as having had a fall in the past year and recently hospitalised or needing support with daily activities, removing environmental fall hazards in the home can reduce the number of falls by 38%. Examples of environmental fall hazards are a stairway without railings, a slippery pathway, or poor lighting. Why is it important to consider environmental hazards as part of a fall prevention programme? Falls are common and can be deadly, but they are preventable. Approximately one-third...

Coordination of care to improve outcomes of emergency medical services This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the effectiveness of interventions aiming to improve coordination of emergency medical services on patient outcomes of emergency care systems. This is a protocol....

What are the benefits and risks of different medications used to treat persistent postural-perceptual dizziness (PPPD)? Key messages We did not identify any studies that assessed the use of medication to treat persistent postural-perceptual dizziness (PPPD). Further work is needed in this area to help establish whether there are any treatments that may be effective at treating this condition, and to check if they cause any unwanted or harmful effects. What is PPPD? PPPD stands for persistent postural-perceptual dizziness. People with this condition have symptoms of dizziness or unsteadiness,...

Mobile health (m-health) technological support for women during pregnancy or the first six weeks postpartum, or both This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess maternal and newborn clinical and psychological outcomes where mobile health (m-health) technological support was given during pregnancy or the first six weeks post birth, or both, compared with different methods of m-health or no health support (usual care). This is a protocol....

Combined pharmacological and psychosocial interventions for alcohol use disorder This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the efficacy and safety of combined pharmacological and psychosocial interventions for the treatment of alcohol use disorder. This is a protocol....