The use of probiotics to prevent Hirschsprung-associated enterocolitis Review question What are the benefits and risks of using probiotics to prevent Hirschsprung-associated enterocolitis (HAEC)? Key messages We compared randomised controlled trials (RCTS) of probiotics versus placebo, or any other non-probiotic intervention, to prevent Hirschsprung-associated enterocolitis (HAEC). There is currently not enough evidence to assess the efficacy or safety of probiotics for the prevention of HAEC. What is HAEC? HAEC is a rare condition. It can cause inflammation of the bowels and lead to...

Surgery on both eyes on the same day or on different days: which works better to treat cataract in both eyes? Key messages - Current evidence supports there may be no important difference between surgery on both eyes on the same day (ISBCS) and surgery on different days (DSBCS) for the following clinical outcomes: eye (ocular) infection (endophthalmitis, a severe, sight-threatening but rare complication), spectacle correction after surgery (refraction), complications, vision with spectacle correction (if needed), and patient-reported outcomes (PROMs; questionnaires on vision). - Current...

Duration of antibiotic treatment for foot osteomyelitis in people with diabetes This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To compare the effects of a shorter antibacterial treatment duration with a longer antibacterial treatment duration in people with diabetes and foot osteomyelitis. This is a protocol....

Fortification of salt with iron and iodine compared to salt fortified with iodine only for improving iron and iodine status Key messages Compared to iodised salt, double-fortified salt (salt fortified with iron and iodine) may improve some measures of iron and iodine nutrition, such as haemoglobin (i.e. the substance that gives red blood cells their colour) concentrations and body iron stores. However, it may reduce urinary iodine concentration and may make little or no difference to ferritin (i.e. iron-storage protein) concentrations and transferrin receptor (i.e. protein that affects the...

Topical and oral steroids for otitis media with effusion (OME) in children This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects (benefits and harms) of topical and oral steroids for otitis media with effusion (OME) in children. This is a protocol....

Autoinflation for otitis media with effusion (OME) in children This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects (benefits and harms) of autoinflation for otitis media with effusion (OME) in children. This is a protocol....

Antibiotics for otitis media with effusion (OME) in children This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects (benefits and harms) of oral antibiotics for otitis media with effusion (OME) in children. This is a protocol....

Can mindfulness help people to stop smoking? Key messages - There is currently no clear evidence that mindfulness-based treatments help people to stop smoking or improve their mental health and well-being. - However, our confidence in the evidence is low or very low, and further evidence is likely to change our conclusions. What is mindfulness? Mindfulness involves focusing attention on your thoughts and feelings and observing them without judgment as they arise and pass away. Mindfulness is believed to help people better control their thoughts and feelings, rather than be controlled by...

Adenoidectomy for otitis media with effusion (OME) in children This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects (benefits and harms) of adenoidectomy, either alone or in combination with ventilation tubes (grommets), for otitis media with effusion (OME) in children. This is a protocol....

Antibiotics for acute pyelonephritis in adults This is a protocol for a Cochrane Review (intervention). The objectives are as follows: This review aims to look at the benefits and harms of antibiotics used in the treatment of acute pyelonephritis in adults. The aspects of treatment that will be evaluated are: Different routes of administration; Different durations of the same antibiotic; and Comparison of different antibiotic agents in the same population. This is a protocol....

Nirmatrelvir combined with ritonavir for preventing and treating COVID-19 This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the efficacy and safety of nirmatrelvir/ritonavir (Paxlovid®) plus standard of care compared to standard of care with or without placebo, or any other proven intervention for treating COVID-19 and for preventing SARS-CoV-2 infection. This is a protocol....

How accurate are remote, virtual assessments at diagnosing dementia? Why is this question important? Dementia is a chronic and progressive condition that affects peoples' memory and ability to function day-to-day. A clinical diagnosis of dementia usually involves brain scans, physical examinations and history taking. As a first step, we often use memory and thinking tests to identify people who need further assessment. Traditionally these tests are performed in-person, but modifications of the tests allow them to be used over the telephone or via video calls – sometimes called 'remote...

Diclofenac for acute postoperative pain in children This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the efficacy and safety of diclofenac (any dose) for acute postoperative pain management in children compared with placebo, other active comparators, or diclofenac administered by either different routes (e.g. oral, rectal, etc.) or strategies (e.g. as needed versus as scheduled). This is a protocol....

Stereotactic body radiation therapy versus more fractionated radical radiotherapy for adults with stage I/II non-small cell lung cancer: a systematic review and network meta-analysis This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness and toxicity of different SBRT schedules (± additional treatments) in comparison with various more fractionated radical radiotherapy schedules (± additional treatments) in controlling primary tumor and prolonging survival in people with early stage NSCLC, and to rank all the schedules based on...

Comparing narrow band imaging to regular cystoscopy for treatment of bladder cancer Review question How does a resection of bladder tissues guided by a special visualization method called narrow band imaging compare to a resection of bladder tissues guided by the standard visualization method (using white light) in people with tumors in their inner bladder wall? Background When people are suspected to have bladder cancer or have been diagnosed with bladder cancer, their doctors need to inspect the bladder closely and remove tissues for further examination. The removal of tumorous tissues...

Remote, face-to-face, and group-based interventions for promoting strength training in healthy community-based adults This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To assess the benefits and harms of remote, face-to-face, and group-based interventions for promoting strength training on participation in healthy, community-based adults. Secondary objectives To assess how the method of intervention delivery (for example the delivering professional, face-to-face versus remote, group-based versus individual, supervised versus...

Prophylactic anticoagulants for non-hospitalised people with COVID-19 This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of prophylactic anticoagulants versus active comparator, placebo or no intervention, on mortality and occurrence of deep venous thrombosis and pulmonary embolism in non-hospitalised people with COVID‐19. This is a protocol....

Psychological and social interventions for the promotion of mental health in people living in low- and middle-income countries affected by humanitarian crises This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the efficacy of psychosocial interventions aimed at promoting mental health versus control conditions (no intervention, intervention as usual, or waiting list) in people living in LMICs affected by humanitarian crises. This is a protocol....

The Rowland Universal Dementia Assessment Scale (RUDAS) for the detection of dementia in a variety of healthcare settings This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To determine the diagnostic accuracy of the Rowland Universal Dementia Assessment Scale (RUDAS) for the detection of all-cause dementia or its subtypes (Alzheimer’s disease, vascular dementia, dementia with Lewy bodies, and frontotemporal dementia) in primary and secondary healthcare settings, and in community-based epidemiological studies (for example, in a cross-sectional prevalence...

Adults' views and experiences of vaccines developed in response to the COVID-19 pandemic: a qualitative evidence synthesis This is a protocol for a Cochrane Review (qualitative). The objectives are as follows: Objectives The objective of this review is to identify, appraise and synthesise qualitative studies that explored adults’ views and experiences towards vaccination in the context of the COVID-19 pandemic. A secondary objective is to compare this evidence with qualitative evidence that explores people’s perspectives of vaccines developed in response to Ebola, Hong Kong flu and...