Drugs to manage pain and sedation during cooling in newborns following poor brain oxygenation at birth (hypoxic-ischaemic encephalopathy) Review question Do drugs save lives, or improve pain and sedation, in newborns who have poor brain oxygenation at birth ('hypoxic-ischaemic encephalopathy') and who are undergoing cooling? Background Lack of oxygen at birth may damage the brain of the newborn. Babies with less severe brain damage may make a full recovery or only have mild problems. For other babies with more serious damage, this may lead to death or to problems later in life. For instance,...

Médicaments empêchant la dissolution des caillots sanguins (thérapie anti-fibrinolytique) pour améliorer la récupération après une hémorragie sous-arachnoïdienne suite à une rupture d'anévrisme Problématique de la revue Quels sont les effets du traitement anti-fibrinolytique chez les personnes souffrant d'une hémorragie sous-arachnoïdienne anévrismale ? Contexte Une hémorragie sous-arachnoïdienne est un saignement dans le petit espace entre le cerveau et le crâne qui contient les vaisseaux sanguins qui alimentent le cerveau (l'espace sous-arachnoïdien). Ce type d'hémorragie est le plus...

Einsatz von Medikamenten, die die Gerinnung im Blut erhöhen und dadurch Blutungen stillen (Antifibrinolytika), nach einer Subarachnoidalblutung aus einem gerissenen Aneurysma (Riss mit anschließender Blutung in den Subarachnoidalraum des Gehirns) Fragestellung Welche Auswirkungen hat eine antifibrinolytische Therapie bei Patienten mit aneurysmatischer Subarachnoidalblutung? Hintergrund Eine Subarachnoidalblutung ist eine Blutung in den Raum zwischen Gehirn und Schädel, in dem die Blutgefäße verlaufen, die das Gehirn versorgen (Subarachnoidalraum). Die Ursache für diese Art von Blutungen ist...

Eine systematische Übersichtsarbeit von Cochrane hat zwei methodisch hochwertige Studien zum Nutzen einer „professionellen Zahnreinigung“ für Erwachsene ohne Zahnfleischentzündung ausgewertet. Demnach ist nicht nachgewiesen, dass eine routinemäßige Zahnsteinentfernung und Politur dazu beitragen, Zähne und Zahnfleisch gesund zu erhalten. In Deutschland …

Professionelle Zahnreinigung: Regelmäßig muss nicht sein ARTIKEL LESEN

Der Beitrag Professionelle Zahnreinigung: Regelmäßig muss nicht sein erschien zuerst auf Wissen Was Wirkt.

Interventions for helping people recognise early signs of recurrence in bipolar disorder This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the effectiveness of EWS plus TAU or EWS plus psychological therapy versus TAU alone or psychological treatment (without EWS) independently on time to recurrence of any bipolar episode and hospitalisation, and other clinically relevant outcome measures. To evaluate the effectiveness of intermittent medication used on recognition of EWS without continued mood-stabilising medication versus TAU involving...

Interventions pour les troubles de la perception après un accident vasculaire cérébral Principaux messages L'accident vasculaire cérébral (AVC) peut altérer la capacité d'une personne à traiter et à comprendre les informations provenant de ses sens, notamment l'ouïe, l'odorat, la somatosensation (perception de la température corporelle, de la position et du mouvement), le goût, le toucher et la vision. Le traitement et la compréhension des informations provenant de ces sens sont appelés la perception. Peu de recherches ont été menées pour savoir si les traitements des problèmes de perception...

Traitements médicamenteux dans la prévention des crises d'angio-œdème héréditaire Qu'est-ce que l'angio-œdème héréditaire et comment est-il traité ? L'angio-œdème héréditaire (AOH) est une maladie grave et potentiellement mortelle qui provoque des crises aiguës (d'apparition soudaine) de gonflement, de douleur et de réduction de la qualité de vie. Plusieurs nouveaux médicaments ont été mis au point pour traiter les crises aiguës et prévenir les crises. Certains médicaments sont pris par voie orale, tandis que d'autres sont injectés sous la peau, ou administrés par une veine directement...

Interventionen bei Wahrnehmungsstörungen nach einem Schlaganfall Kernaussagen Ein Schlaganfall kann die Fähigkeit einer Person beeinträchtigen, Sinneseindrücke zu verarbeiten und zu verstehen, einschließlich Hören, Riechen, Schmecken, Tasten und Sehen. Auch die Somatosensibilität (Wahrnehmung von Körpertemperatur, -position und -bewegung) kann beeinträchtigt sein. Das Verarbeiten und Verstehen von Sinneseindrücken wird als Wahrnehmung bezeichnet. Es gibt nur wenige Untersuchungen dazu, ob es Behandlungsmaßnahmen gibt, die bei schlaganfallbedingten Wahrnehmungsstörungen hilfreich sind....

En bloc versus standard transurethral resection of bladder tumors for non-muscle-invasive bladder cancer patients This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of en bloc resection compared with conventional transurethral resection of the bladder tumor (conventional TURBT) in patients with non-muscle-invasive bladder cancer. This is a protocol....

Volatile pyrethroid spatial repellents for malaria prevention This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness of volatile pyrethroid spatial repellents (VPSRs) for preventing new cases of Plasmodium falciparum and Plasmodium vivax malaria. This is a protocol....

Drug treatments for the prevention of attacks of hereditary angioedema What is hereditary angioedema and how is it treated? Hereditary angioedema (HAE) is a serious and potentially life-threatening condition that causes acute (sudden onset) attacks of swelling, pain and reduced quality of life. Several new medicines have been developed to treat acute attacks and prevent attacks from occurring. Some medicines are taken by mouth, whereas others are injected under the skin, or given by a vein directly into the blood. The medicines currently given for preventing HAE attacks are human C1 esterase...

Immunomodulators and immunosuppressants for progressive multiple sclerosis: a network meta-analysis This is a protocol for a Cochrane Review (intervention). The objectives are as follows: We will perform a network meta-analysis to assess the relative effectiveness and safety of immunomodulatory and immunosuppressive treatments for people with multiple sclerosis in progressive forms of the condition. This is a protocol....

Prognostic factors for predicting progression of open angle glaucoma in adults This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: Primary objective To identify prognostic risk factors for progression of functional visual outcomes of primary open angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXFG) in adults. Table 1. PICOTS of the primary objective Population Adults ≥ 18 years of age of any ethnicity with open angle glaucoma (restricted to POAG and PXFG types) diagnosed as having open angle and evidence of glaucomatous damage. We will exclude studies...

Interventions for preventing haemodialysis dysequilibrium syndrome This is a protocol for a Cochrane Review (intervention). The objectives are as follows: This review aims to look at the benefits and harms of interventions for preventing HD DDS. This is a protocol....

Traitement médicamenteux des affections inflammatoires de l'œil Quel était l’objectif de la revue ? Dans cette revue systématique, nous avons étudié les données probantes disponibles sur l'efficacité et la sécurité de plusieurs médicaments utilisés pour traiter un sous-ensemble spécifique d'affections inflammatoires de la partie postérieure de l'œil. Principaux messages Nous avons constaté que le médicament méthotrexate serait légèrement plus efficace que le mycophénolate. Autrement, il n'y avait pas de données probantes solides suggérant qu'un médicament est plus efficace ou plus sûr...

Effects of different weight loss programmes on oncological outcomes following curative resection of digestive tract cancers This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effect of different weight loss programmes on oncological outcomes following curative resection of GI tract cancers. This is a protocol....

Interventions for improving adherence to dietary salt and fluid restrictions in people with chronic kidney disease (stage 4 and 5) This is a protocol for a Cochrane Review (intervention). The objectives are as follows: This review aims to look at the benefits and harms of non-pharmacological interventions to improve adherence to dietary salt and fluid restriction in people with CKD (stages 4 and 5). This is a protocol....

Health policymakers’ views and experiences of knowledge translation approaches to facilitate evidence-informed decision-making: a qualitative evidence synthesis This is a protocol for a Cochrane Review (qualitative). The objectives are as follows: The aim of this review is to synthesise the qualitative evidence on health policymakers’ views and experiences of knowledge translation approaches to facilitate evidence-informed decision-making. The specific objectives are to: explore health policymakers’ views and experiences of knowledge translation approaches to facilitate evidence-informed...

Treatment of inflammatory conditions of the eye with medications What was the aim of this review? In this systematic review, we studied the available evidence on the effectiveness and safety of several medications used to treat a specific subset of inflammatory conditions of the back part of the eye. Key message We found that the medication methotrexate may be slightly more effective than mycophenolate. Otherwise, there was no strong evidence to suggest one medication is more effective or safe than the others. What did we study in this review? Non-infectious intermediate, posterior, and...

In a blog for healthcare professionals Dr James Garrard, Registrar in Geriatric Medicine, looks at the importance of recognising frailty in older adults and the latest evidence on Comprehensive Geriatric Assessment.

The post Recognising and managing frailty in older adults appeared first on Evidently Cochrane.